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How it Works
The mucoadhesive moisture barrier of VIRALEZE™ contains astodrimer sodium, proven in laboratory studies to physically trap and block cold/respiratory viruses, helping to reduce their adhesion, multiplication and spread, allowing your body’s natural defences to remove the viruses from the body.
Astodrimer sodium in VIRALEZE™ is not absorbed into the bloodstream.
The nasal cavity is the primary site where cold/respiratory viruses become established before a cold/respiratory infection develops.
Mucus is naturally produced in the nose and its role is to trap foreign particles, including viruses, and reduce the chance of them infecting cells in the nasal cavity and entering the lungs. The mucoadhesive formula of VIRALEZE™ provides an additional moisture barrier in the your nose that aims to help hydrate keep the nasal mucosa hydrated for protection against mucosal drying and damage, thereby supporting your body’s natural defenses against viruses.
VIRALEZE™ contains astodrimer sodium, proven in laboratory studies to physically trap and block cold/respiratory viruses^, helping to prevent their adhesion to the nasal mucous membrane.
^Gallay et al., Top Antiv Med, 2022, 30(1s), 478
Paull JRA et al., Antivir Res, 2021, 191, 105089
Paull JRA et al., Viruses, 2021, 13, 1656
Testing of astodrimer sodium was conducted at The Scripps Research Institute, USA and 360biolabs, Australia.
Astodrimer sodium acts by physically blocking the interaction between cold/respiratory virus “spikes”, or surface proteins, and the human cells the virus is seeking to infect.
“Spike” or other proteins on the surface of cold/respiratory viruses that come into contact with VIRALEZE™ are physically trapped and blocked by astodrimer sodium.
This mechanism provides a physical barrier to cold/respiratory viruses in the nasal cavity. The trapped and blocked cold/respiratory viruses are eliminated naturally with the nasal mucus.
Performance of astodrimer sodium (SPL7013) against cold/respiratory virus vs. iota-carrageenan
Astodrimer sodium trapped and blocked respiratory viruses with 30x more potency than iota-carrageenan in a cell-based laboratory assay.
The assay comparing astodrimer sodium (SPL7013) and iota-carrageenan (Sigma-Aldrich, MO, USA) against this cold/respiratory virus was conducted in Vero E6-hACE2-TMPRSS2 cells, according to standard virological methods, such as those described in Paull JRA et al., Antivir Res, 2021, 191, 105089.
